Arteriosclerosis is a group of diseases characterized by thickened and hardened walls of arteries. This condition can lead to high blood pressure and heart disease. Due to changes in lifestyle, atherosclerosis is very common even among children.
Plaque buildup on artery walls occurs naturally as we age, but the process is accelerated by smoking, alcohol consumption, high fat diet, caffeine and lack of exercise. Stress is another risk factor. Inheritance and some diseases, particularly diabetes, also contribute. All this points to the importance of maintaining a healthy diet and lifestyle, which will certainly be a help to avoid this dangerous disease.
Gamma tocopherol ascorbic acid are the most important antioxidants, and have shown a role in preventing stroke and arteriosclerosis arterioskleroze.Glavni cause the deposition of LDL or bad cholesterol in the interior wall of blood vessels. Antioxidants have the ability to reduce LDL and HDL or good cholesterol, which ultimately leads to the removal of deposits from the blood žila.Odgovarajući share of the above antioxidants are very effective against the fear filled diseases such as atherosclerosis, cancer and astme.Lijek now available against diseases such as arteriosclerosis, it has side effects. Instead, consider using herbal solutions without the risk and they will help to protect against other diseases.
Vitamin E is a term for a group of tocopherols and tocotrienols. Vegetable oils are major dietary sources of vitamin E (560-1600 mg / kg in soybean oil, 530-1620 mg / kg in corn oil, and 50-150 mg / kg in olive oil, sun flower oil, meat (0.5 - 1.6 mg / kg), poultry (1.6 to 4.0 mg / kg) and dairy products (0.4 to 10.0 mg / kg) provides only moderate amounts. High intake of vitamin E are associated with reduced risk of cardiovascular disease.
In 1996, Cambridge Heart Antioxidant Study (CHAOS) (23) reported more than 2000 patients with coronary atherosclerosis angiographically proven that vitamin E supplementation (400-800 IU / day) for a little under 2 years significantly (P, 0.005) reduced the incidence of cardiovascular death and MI myocardial infarction by 77%. Decreases in lipid peroxidation and low density lipoprotein (LDL) are supposed to be mechanisms for the rezultat.Uloga different from oxygen radical scavenging has been proposed for gamma-tocopherol.
In contrast to alpha-tocopherol, gamma-tocopherol is a powerful nucleophile that traps electrophilic mutagens in lipophilic compartments. Thus, glutathione supplements, which similarly scavenges electrophilic mutagens in the aqueous phase stanice.Electrophilic mutagenic prone to react with the g-tocopherol is peroxynitrite. Thus, g-tocopherol may protect lipids, DNA and protein damage by peroxynitrite dependent.
Vitamin E acts as a chain breaking antioxidant that prevents the spread of free radicals reakcije.Reakcije between alpha-tocopherol and free radicals leads to the formation of oxidative end products, such as-tocopherol hydroquinone, 5, 6 epoxy tocopherolquinone, 2, 3 epoxy tocopherolquinone. This ultimately leads to the termination of lipid peroxidation in the consumption of free radicals.
Vitamin E appears as an anti-cancer agents.
When compared to alpha tocopherol, gamma-tocopherol inhibits growth and causes cell death by prostate and lung cancer cells but has no effect on normal prostate epithelial cells. The study shows that gamma-tocopherol induce cell death by interrupting sphingolipid synthesis. This is due to the molecular interaction between vitamin E and various forms of key enzymes in the pathway of synthesis de novo sphingolipids.Uloga these enzymes in cell fate, and testing anti-cancer potential of vitamin E in various cancers in animal models. Vitamin E appears as an anti-inflammatory agentima.Interakcija between vitamin E and various forms of cyclooxygenase and lipoxygenase, as well as the role of vitamin E in gene regulation during inflammation, which is not well understood.
Forms of Vitamin E and asthma
The airway inflammation in asthma, the neutrophil myeloperoxidase and eosinophil peroxidase from eosinophils generate very powerful oxidants that cause oxidative štete.Štete caused by the peroxidase can be reduced by vitamin E and other forms of antioksidansi.Peroksid ions such as hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and the chloride anion (Cl-) released during the neutrophil's respiratory burst can cause serious tissue damage. Gamma-tocopherol is the reduction of energy is very effective in reducing the intensity of tissue damage. Gamma-tocopherol protects the nose or lungs allergen provocation way to block infiltration oesinophils the airspace, lung tissue, nose and sinuses.
Action ascorbic acid to prevent arteriosclerosis
Vitamin C is an antioxidant vitamin is required for the formation of collagen to hold cells together and for healthy teeth, gums and blood vessels, enhances iron absorption and resistance to infection. Vitamin C is found in many fresh fruits and vegetables such as broccoli, green and red peppers, collard greens, cauliflower, lemon, cabbage, pineapple, strawberries and citrus fruits.
Vitamin C serves as a key immune system nutrient and a potent free radical fighter. This nutrient has been shown to prevent many illnesses, from everyday illnesses like colds devastating diseases such as cancer and arteriosclerosis. Ascorbic acid acts marked inhibitory effect on the development of atherosclerosis. Atherosclerosis, which develops in guinea pigs,
as a result of ascorbic acid depletion has all the characteristics of human atherosclerosis.
Plasma cholesterol levels of these animals were normal and no lipid deposit in the reticule-endothelial system. Ascorbic acid deficiency is usually not considered to exist in people with atherosclerosis, where the food seems good. Recent biochemical studies indicate that the radioactive acetate incorporated into cholesterol was significantly faster in tissues depleted of ascorbic acid.
As an antioxidant and an integral part of collagen, vitamin C may play multiple roles in maintaining cardiovascular fitness. It affects some important aspects of functioning kardiovaskularnog.Masnih plaques that form in blood vessels, called atherosclerosis, the major contributor to heart disease, vitamin C can help prevent plaque inhibits oxidative modification of low density lipoproteins (LDLs), according to a study conducted at the University of Texas southwestern Medical Center. LDLs, also known as "bad" form of cholesterol, can "contribute to the atherosclerotic process by cytotoxic effects
In addition, vitamin C may play a role in alleviating another aspect of atherosclerosis - the buildup and adhesion of platelets to blood vessel walls, vessel wall injury stimulates production of prostaglandin called thromboxane. This prostaglandin causes platelets to aggregate and clot. On the other hand, prostaglandin called Prostacyclin helps protect against the effects of this process.
In humans, studies, vitamin C in doses of 1-2 grams per day has been shown to interfere with platelet aggregation and adhesion, reducing the level of oxidation by-product of platelets, and increased fibrinolytic activity, which may help to clear arteries. Animal studies have found that vitamin C can prevent or reverse plaque formation caused by high cholesterol diet, reduced platelet aggregation stimulated production of prostacyclin, and interfere with the platelet release mechanism, thereby reducing platelet activity.
Too much cholesterol can lead to heart disease. However, studies on the relationship between vitamin C in blood cholesterol levels report mixed human studies have noted a positive correlation between blood levels of vitamin C and high density lipoproteins (HDLs). In contrast to LDLs, which can lead to plaque, HDLs help reduce the risk of heart disease, "cleaning" cholesterol. Researchers monitor cholesterol levels than people who are 1500 mg of vitamin C daily.
Found that cholesterol levels were significantly decreased because vitamin C promotes the conversion of cholesterol to bile acids, which are then eliminated from the body in the feces, etc., several animal studies have shown that vitamin C helps stimulate the conversion enzyme that regulates the process . In addition, vitamin C can increase the beneficial HDL cholesterol. Ischemic heart disease, as well as other antioxidants, vitamin C can protect an area of the heart deprived of oxygen from further damaging free radicals.
Studies show that vitamin C is an antioxidant mechanisms may help prevent cancer in several ways. To fight against the peroxidation of lipids, for example, which was associated with the process of aging and degeneration. One study of elderly people found that 400 mg of vitamin C per day (one year) decreased serum levels of lipid peroxide. Vitamin C can also operate within cells to protect DNA from damage caused by free radicals. Vitamin C also decreases the level of potentially destructive changes in the genetic or chromosomal aberrations.
Diabetes, tissues and organs in diabetic patients may be deprived of vitamin C, which require them to consume more nutrients than the average person. Vitamin C has to compete with glucose to tissues and organs through a common cellular transmission sustava.Nedovoljna supply of insulin can also prevent the transport of vitamin C on cells that require insulin for glucose uptake.
As an antioxidant, vitamin C can rejuvenate vitamin E, which is an indirect contribution to the fight against free radicals in lipids. These two nutrients can be effective partners in reducing the destructive process of lipid peroxidation. In human and animal studies, this reduction took place in patients with diabetes, cerebral arteriosclerosis or heart disorders. Together, vitamins C and E may help prevent blood from clotting, provided that it contributes to the risk of stroke.
Synergistic combination of vitamins C and E can be further improved by adding vitamin A. In one study of 30 elderly long-stay patients, for example, this trio is effective in improving certain aspects of cell-mediated immunity, such as the number of T cells , T4 subsets and the ratio of T4 to T8 cells. In another study, a complex of vitamins A, E and C significantly improved "characteristics of enzymatic and non-enzymatic antioxidant protecting the liver" in mice.
An adequate intake of tocopherols and ascorbic acid is assumed to reduce the risk of terror filled with diseases such as cancer and atherosclerosis and reduce oxidative damage these antioxidants in purified form is almost twice than from natural sources, but in this case the chemical synthetic forms of antioxidants are less reactive than naturally occurring forms. My goal is to characterize the proper dosage with the help of some relevant studies on antioxidants and to provide supplementary food as a drug to prevent dangerous diseases like cancer, asthma and arthrosclerosis.
